CADASIL

CADASIL[Diseases]

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Name：Cortical hypometabolism and crossed cerebellar diaschisis suggest subcortically induced disconnection in CADASIL: An (18)F-FDG PET study : An article from: The Journal of Nuclear Medicine Catalog:Ebook Release:13 September, 2005 Manufacturer:Society of Nuclear Medicine SalesRank: Available for download now

CADASIL CADASIL stands for Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy and is a genetic disorder characterised by migraines with aura and cerebrovascular disease causing dementia and stroke. The disease is caused by a Genetic mutation|mutation of the NOTCH3 gene. Some patients also experience mood disorders and epilepsy. CADASIL brain damage is characterized by subcortical infarcts, white matter damage and microbleeds. An ultrastructural analysis shows small caliber arterial damage, consisting in smooth muscle cells loss, swollen endothelial cells and osmiophilic deposits. There is some evidence showing that clinical progression depends on the mutation's localization in the Gene sequencing|gene sequence.CADASIL has only recently been discovered and only around 400 families with the disease have been diagnosed. However, it is believed that the disease is far more prevalent than current diagnoses indicate. quote Wikipedia - Article - History - License:GFDL

Diseases　Renewal 2005.10.22　 Exploding head syndrome / Postweaning multisystemic wasting syndrome / Mastoiditis / Laryngeal papillomatosis / Space adaptation syndrome / CADASIL / Kyphosis / Altitude sickness / Sea-sickness / Heart rot / Spinocerebellar ataxia / Cervical spine disorder / Scoliosis / Digestive diseases / AIDS / Plantar fasciitis / Osteochondrosis / Aseptic bone necrosis / Third Pandemic / Arthritis